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WaterSolutions APIs

Dow supplies two Active Pharmaceutical Ingredient (API) intermediates: cholestyramine and polystyrene sulfonate (PSS), used respectively for cholesterol and potassium reduction.

API Applications

HYPERKALIEMA

Excess potassium in the blood is a common condition in chronic renal failure and is potentially life-threatening. The action of the functional polymer is simple ion exchange; the polymer is in the sodium form and the sodium ions are exchanged with the excess potassium in the blood stream as the resin passes through the GI tract. Typical dosage amounts are 15-60 g per day for extended periods of time. Formulations are either powder sachets or aqueous suspensions.

HYPERCHOLESTEROLEMIA

Cholesterol is known to be a key intermediate in the biosynthesis of bile acids present in the human GI tract, and removing these bile acids from the body has the added effect of removing cholesterol. Anionic exchange resins can bind with bile acids and effectively removed from the body. Typical dosage amounts are 8-24g per day for extended periods. A number of different formulations are commercialized although the predominant one is a powder sachet or small container.

Learn more about Dow's
Advanced Release Technology
@ www.theartofformulation.com

WaterSolutions APIs

API Applications

HYPERKALIEMA

HYPERCHOLESTEROLEMIA

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